Genetics: From Molecule to Society

نویسندگان

  • Michel G. Nivard
  • Dorret I. Boomsma
چکیده

A genome-wide association study of neighborhood characteristics and family income finds heritability, identifies single nucleotide polymorphisms and shows genetic correlates of these traits with numerous other health and cognitive traits. Different mechanisms behind genetic correlations imply different interpretations of association and causality.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

اخلاق و اولویت‌بندی در ژنتیک اجتماعی

Abstract Community genetics is an applied research area that explores the role of genetic variables on the interactions and community structure determinism affecting species. Community genetics covers a spectrum from services, genetic and congenital disorders, genetic counseling, prevention and screening to macro policies. The focal point of community genetics is the society, and community-o...

متن کامل

Chemical genetics to chemical genomics: small molecules offer big insights.

Chemical genetics is the study of biological systems using small molecule ('chemical') intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field...

متن کامل

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.

The increasing diversity of small molecule libraries has been an important source for the development of new drugs and, more recently, for unraveling the mechanisms of cellular events-a process termed chemical genetics.(1) Unfortunately, the majority of currently available compounds are mechanism-based enzyme inhibitors, whereas most of cellular activity regulation proceeds on the level of prot...

متن کامل

NMR distinction of single- and multiple-mode binding of small-molecule protein ligands.

Identifying and characterizing small-molecule inhibitors of protein-protein interactions is of high interest for drug discovery and for chemical genetics studies of biological pathways. Very often, initial hits or first-generation compounds have low micromolar dissociation constants and cause line broadening in NMR spectra. It is very important for subsequent structure-based compound optimizati...

متن کامل

HLA-G بررسی ساختار و عملکرد

HLA-G is a nonclassical HLA class Ib, which is located on chromosome 6 (6p.21.3). In contrast to HLA class I molecules, HLA-G has restricted polymorphism. Expression of this molecule in the physiological conditions limits to certain tissues such as thymus, cornea, nail matrix, trophoblast and pancreas. Up to now, 50 alleles of HLA-G molecules have been discovered with 16 distinct functional pro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Current Biology

دوره 26  شماره 

صفحات  -

تاریخ انتشار 2016